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SomaLife gHP Science & Research


SomaLife gHP, a product for the new millennium, was conceived, developed and tested by a world-renowned team of physicians and biochemists who are in the emerging field of longevity medicine. Classified as a nutritional supplement, SomaLife gHP is a critical combination of amino acids, which, when taken orally, has the potential to stimulate the pituitary gland to secrete growth hormone. Growth hormone is recognized not only to be important in promoting growth in children, but also in maintaining cellular integrity thereafter.

The rationale behind the development of SomaLife gHP was the well documented association between aging and the decline in the release of growth hormone, which occurs after growth is completed around age eighteen. Recognition of this association led to the use of growth hormone injections during the 1990s by the 'rich and famous' who could afford this expensive exercise, and thereby enjoy the evident anti-aging effects.

SomaLife gHP, on the other hand, offers the same longevity effects, but with a relatively inexpensive oral product which is being enthusiastically received by a rapidly expanding group of several thousand users. Evidence of SomaLife gHP's acceptance would appear to be validated by the continued use of the product (at an affordable cost), accompanied by positive testimonials on its effectiveness. Because the amino acids in SomaLife gHP are some of those normally used by the body in cellular metabolism and protein production, the potential elevation of growth hormone levels cannot exceed normal levels for an individual. So consequently, significant negative effects have not been observed or reported, and are not expected.

SomaLife gHP is manufactured from the highest quality, imported amino acids under carefully controlled conditions. Each batch of the product is subjected to high quality control testing before it is released to the central distribution centre. SomaLife's sophisticated computerized system, together with its well trained and motivated staff, ensures timely fulfillment of product delivery following registration of a user with SomaLife Health Products Inc.

Moe S. Aziz BSc (Biochemistry), MBA
President & CEO of Sino Pharmaceuticals

Preface - With the beginning of the 21st century, a multitude of exciting changes are occurring in concepts related to aging. These changes have resulted in an exploding body of knowledge regarding the aging process -- in both humans and animals. We are now at the forefront of applying much of that recently acquired knowledge in ways that will enable us to slow, and in some cases, stop or even reverse some of the changes associated with aging.

This information booklet is designed to provide you with some of the latest anti-aging science that is occurring in the world today. It also demonstrates the potential, and how we may all benefit from this huge body of scientific work. Applying this knowledge may well be the promise of an 'ageless life' made better, brighter, and healthier.

One of the most exciting developments currently taking place is the acquisition and application of knowledge about human growth hormone (HGH) and its potential for literally turning back the clock of life. Until recently, human growth hormone was available only in expensive injection forms, so benefits from the restoration of HGH levels were only available to those with the ability to pay large fees. Now, natural substances called Secretagogues have become available. Secretagogues can trigger the release of human growth hormone from an individual's anterior pituitary gland. They actually have the ability to restore HGH levels to the levels found in one's youth. This booklet tracks some of the fascinating history behind HGH research and its application. It also covers the current state and availability of that research, and its potential for age reversal.

Enjoy the read!

Can We Really Turn Back The Clock? - For thousands of years humans have dreamed about the ability to attain immortality. Although immortality will probably remain a dream forever, we are much closer to understanding what it is that causes cells (and therefore the body) to age and how to slow or even stop that process

Over the centuries, the ongoing quest for the ultimate 'fountain of youth' has fostered all kinds of substances, and claims for them, as our society has restlessly sought the answer to that common question, "Why do we age?" Over the past twenty years, a vast body of scientific knowledge on the aging process has been accumulated. Recently, we have been able to apply that knowledge and make the application available at an affordable price to the population at large. Scientists in the field of anti-aging feel that, in the relatively near future, the average life expectancy of a healthy individual will be extended to one hundred years or more. The first steps along that pathway have already occurred with the potential to restore the levels of human growth hormone (HGH) to those of our youth with simple, affordable, and natural substances. Human growth hormone (HGH) in our current state of knowledge is the 'ultimate anti-ager'. Exciting developments in DNA and chromosome research are just around the corner.

Doctors' Secrets - The Road to Longevity, by Dr. Donald McLeod (President of the Canadian Longevity and Anti-Aging Academy), and Dr. Philip White (Vice President of the Canadian Longevity and Anti-Aging Academy) is based on scientific papers published in the last twenty to thirty years, and is accompanied by an extensive bibliography. In their book they refer to HGH as the "time machine" of the human body. Dr. Ronald Klatz (President of the American Academy of Anti-Aging Medicine) has announced that the "ageless society has truly begun." He is not alone in this statement

The advent of better nutrition, socio-economic conditions, better treatment of disease, supplements, anti-oxidants, and other benefits to human society, lead experts to believe that now the human body can live well into the hundred and twenties or even hundred and forties, and in a healthy condition, particularly with the help of such discoveries as the effects of HGH.

Where Did It All Start? - Over the years, world-renowned clinics such as Ana Aslan's in Romania, and the Clinique La Prairie in Switzerland have attracted thousands of people, mostly the rich and famous. They have sought treatments that include injections of Gerovital H3 or fresh foetal lamb cells. Such treatments may have had some merit in the past but none have passed the gold standard of clinical trials for such interventions. This began to change about twenty years ago.

In 1981 a study was published from the University of Rome by Drs. Isidori, Lo Monico and Cappa, which demonstrated that a specific combination of amino acids, when ingested orally, would cause an increase in growth hormone levels in humans. This landmark study demonstrating the ability to orally elevate HGH was of considerable importance in clinical and diagnostic practice. It offered a more practical and physiological approach to the previously known fact that intravenous administration of some amino acids strongly stimulates the secretion of growth hormone (HGH) by the anterior pituitary gland.

During the 1980s a significant amount of work was done on human growth hormone, particularly after it was found that it could be synthesized by recombinant DNA technology. But it was still only available in an injected and expensive form. Although costs have come down somewhat, the fee per month for human growth hormone injections can be as high as $2,800.00 US.

In 1990 Dr. Daniel Rudman, an endocrinologist from Madison, Wisconsin, published a ground-breaking research paper in the world-renowned New England Journal of Medicine. This study, which shook the medical world, showed that twelve healthy men between 61 and 81, following six months of human growth hormone therapy, had age reversal effects on lean body mass and adipose tissue (fat) mass equivalent in magnitude to changes attributable to ten to twenty years of aging. In addition, Dr. Rudman noted that alterations in body composition caused by growth hormone deficiency as we age, can be reversed by replacement doses of hormone in other species as well as humans. Dr. Rudman also noted "that these findings suggest that the atrophy of lean body mass and its (the body's) component organs, and the enlargement of the mass of adipose tissue (fat) that are characteristic of the elderly, result at least in part from diminished secretion of growth hormone. If so, the age-related changes in body composition should be correctable in part by the administration of human growth hormone, now readily available as a bio-synthetic product." Since that time, large numbers of additional studies have supported the fact that HGH can retard, as well as possibly reverse, at least some parameters of the aging process.

The largest study to date of the effects of growth hormone on humans has been that of Dr. Edmund Chein at the Palm Springs Life Extension Institute in association with Dr. Leon Terry, a Neuroendocrinologist from the Department of Neurology at the Medical College of Wisconsin. Interestingly, it was the Medical College of Wisconsin that produced the landmark study by Dr. Rudman in 1990. The Palm Springs Life Extension Institute follows a growth hormone protocol which restores HGH levels in patients with low IGF-1 levels with low dose, high frequency injections. Dr. Chein's study is ongoing and his patients now number in the thousands.

The Palm Springs Life Extension Institute combines HGH injections with other hormones that might be low, and has developed a program that is claimed to have been 100% effective for all of its patients with a protocol that continues until the patient has attained the body composition of a younger person. The earlier collected data of patients who have been treated at the Life Extension Institute has been published. The assessment figures were obtained from randomly selected, self-assessment questionnaires completed by two hundred patients during the term of the therapy from 1994 to 1996

Looking And Feeling Younger - As noted earlier, human growth hormone (HGH) is considered to be the 'ultimate anti-ager' and affects almost every cell in the body. Its primary purpose is that of stimulating growth, regeneration and cell repair. Once the growth period is over, its primary function becomes that of cell regeneration and repair. The immune system and other systems in the body appear to benefit as well. Dr. Rudman's study demonstrated that bone density in the lumbar spine can improve. It has also been shown that wrinkled skin diminishes, while others have experienced improvement in presbyopia (the difficulty in focussing due to hardening of the lenses as we age). Some people have even reported restoration of hair colour and growth. HGH appears to selectively reduce the fat around the abdomen, hips, waist and thighs while at the same time increasing muscle mass. In Dr. Rudman's study, after six months of usage, without exercise, the subjects had an average 8% increase in lean muscle mass and a 14.4% loss of fat.

75% of the individuals studied described an increase and improvement in sexual function as well as increased frequency of sexual relations. 60% of male individuals studied experienced improvement in duration of penile erection. Energy levels were improved in 84% of individuals and muscle strength improved in 88%.

HGH not only has the potential to restore sexual function and sexuality in older men but also acts as a mood elevator, restoring a youthful sense of wellness and joie de vivre as well as improving sleep. With its ability to affect cell regeneration and repair, healing of injuries should improve. It appears more benefits are coming to light as each new study is published.

Human Growth Hormone (HGH) - Human growth hormone or HGH (medical name Somatotropin) is produced in the anterior pituitary gland situated just below the hypothalamus, which is itself situated just below the cerebral cortex of the brain. HGH is one of several hormones secreted by the anterior pituitary gland and influences the growth, regeneration and repair of cells, and therefore bones, muscles and organs throughout the body during life. Production of HGH peaks at adolescence when accelerated growth is occurring. If growing children are deficient in human growth hormone, they remain as pituitary dwarfs, whereas if they have too much, they exhibit gigantism (acromegaly).

As is the case with many of our other hormones or their pre-cursors, such as testosterone, oestrogen, progesterone, DHEA and melatonin, HGH levels decline with age. Therapeutically, many of these hormones can be replaced to offset some of the effects of aging such as menopausal symptoms in women or erectile dysfunction in men. Replacement of HGH in individuals has, as previously described and documented, the potential to reverse many of the other effects of aging, and the potential for HGH age reversal is now available in a simple, relatively inexpensive form.

The human body, like every living entity, works on daily, or circadian, as well as monthly and annual rhythms. Daily growth hormone secretion diminishes with age with roughly half the levels at age forty that we had when we were twenty, and about one-third of those youthful levels at age sixty. In some sixty-year olds the levels are as low as 25% of the HGH levels in a twenty-five year old. Symptoms of aging include loss of muscle, increase in fat, decreased physical mobility, decreased energy levels and as a result, diminished socialization, diminished healing ability and decreasing life expectancy. Many medical authorities now consider aging to be no longer just a physiological process that is inevitable. Cells do have the ability to not age, as has been demonstrated in the last few years by growing human cells in tissue culture and then applying certain biochemical manipulations to them.

It is now thought that the decline of growth hormone with age is directly associated with many symptoms of aging including wrinkling, grey hair, decreased energy, sexual function, and increased body fat and that many of those symptoms are reversible.

Many of the symptoms of aging have been found in younger adults who have growth hormone deficiency. Those individuals have a biological age which exceeds their chronological age. The good news from all of this research is that clinical evidence has demonstrated that by replacing growth hormone we can dramatically reverse symptoms attributable to aging, improving energy, reducing body fat, and increasing muscle mass and strength, as well as a host of other potential health benefits.

HGH, once released by the pituitary gland, travels in the circulation and is taken up principally by the liver where it stimulates the production of another hormone-like substance called Insulin-like Growth Factor -1 (IGF-1). IGF-1 is then released into the circulation where it attaches to cells in the body, and like insulin, triggers the cell to produce certain responses which, with IGF-1, are those of growth, regeneration and repair.

Levels of IGF-1 are monitored by the hypothalamus situated just above the pituitary gland. When maximal HGH levels are attained for any individual, these levels trigger the release of Somatostatin, another brain chemical, which 'shuts the gate' in the pituitary gland, preventing further release of HGH or Somatotropin, as it is medically called. This feedback loop prevents excessive levels of HGH in the body. Feedback loops are extremely efficient at preventing our hormone levels from exceeding our optimal levels.

Secretagogues - The ground-breaking research by Isidori, et al, at the University of Rome in 1981, and particularly that of Dr. Daniel Rudman in 1990, has led to the development of dietary supplements which have the ability to trigger HGH release from the human anterior pituitary gland. As noted previously, until recently, growth hormone therapy was very expensive and available only through injections with the added difficulty of needing constant monitoring. Prices ranged from $800 to $2,800 US per month, depending on the source, the supply and levels of monitoring. These prices remain out of range for most people and there are still dangers associated with injecting human growth hormone, as there is the potential for over dosage and related problems.

A Secretagogue is any product that is designed to promote the release of a hormone. Recently, the ground breaking research at SomaLife Health Products has been instrumental in the discovery of a Secretagogue that works to release Human Growth Hormone. It is safe, reliable, effective, and available at a price that is within the range of most people in the target groups. There are two very large populations who could significantly benefit from improved HGH levels: these are the 'Baby Boomer' generation as well as anyone over 25 years.

Secretagogues in this instance are nutrients designed to encourage the anterior pituitary gland to release its own growth hormone which it continues to make in substantial quantities throughout life. It has been demonstrated that as we get older we still produce HGH, but our serum levels fall as a result of not releasing it. Secretagogues reverse this process naturally and maintain the body's own natural feedback loop, thus releasing HGH naturally and safely. Those Secretagogues are natural substances, which have been well documented, as previously noted in the 1981 University of Rome study, to increase growth hormone levels. According to some researchers, these natural HGH releasers may have the ability to more closely mimic the body's youthful HGH secretion patterns than any other HGH therapies currently available.

Use of a Secretagogue, such as SomaLife gHP, has the potential for restoring the body's HGH and IGF-1 levels to those of youth with all the potential benefits. There are no other substances available, short of injecting HGH, that appear to have as far-reaching an ability to realize the potential for prevention and reversal of the aging process.

Prior to Dr. Rudman's landmark study of 1990, growth hormone was used for many decades as early as 1920, for those unfortunate children who had pituitary hormone deficiency. Originally, prior to being able to synthesize HGH
through DNA recombinant technology, it was available only
through cadavers (extracting it from the pituitary gland) which was not always a safe or easy process, as well as being very expensive. Observations of those children produced a wealth of knowledge regarding the effects of HGH. This knowledge has been substantially built upon over the last twenty years.

Dr. Rudman's conclusion, that "the overall deterioration of the body that comes with growing old is not inevitable," has been borne out with subsequent studies showing that HGH may reverse many parameters of the biological aging process. Some of the beneficial effects are:

  • Increasing energy
  • Improving memory
  • Improving sexual function
  • Improving vision
  • Restoring muscle mass
  • Improving blood pressure
  • Reducing body fat
  • Elevating mood and improving sleep
  • Thickening the skin
  • Increasing cardiac output and stamina
  • Improving immune function
  • Restoring hair colour
  • Restoring lost hair
  • Improving cholesterol profile
  • Reducing wrinkles
  • Restoring size of liver, pancreas, heart and other organs that shrink with age.

Where Are We Now? - Since the publication of those landmark studies, others have shown that if the body's growth hormone releasing pattern is mimicked more closely, the effects of normalizing levels are more profound and side effects are minimized. The natural secretagogue SomaLife gHP appears to offer the best opportunity for doing this in a natural and physiological way without interfering with the body's feedback loop.

Dr. Klatz, President of the American Academy of Anti-Aging Medicine (A4M), noted in his book, Grow Young With HGH, that "some of the best HGH releasers were the amino acids. These, in combination with a dietary programme and exercise, can offer results which are very significant." SomaLife gHP contains the right amino acids in the correct proportions and specific quantities to contribute to optimal HGH release, formulated in a proprietary and specific way to ensure its maximum effect as a dietary supplement. SomaLife gHP is not a drug!

Some amino acids can be made in the body from basic building blocks, but others (nine out of the twenty needed for protein building) are called essential amino acids, as the body is unable to manufacture them and they have to be supplied in the food that we eat. Arginine is an amino acid important in creatine synthesis. Claims for Arginine include an increase in fat-burning and muscle-building, as well as strengthening the thymus gland by increasing its weight and activity and thereby boosting immunity. There are also claims in the literature that Arginine alone will promote healing of burns and wounds as well as enhance male fertility. Arginine, along with Lysine, was one of the amino acids demonstrated in the 1981 study to cause HGH release when combined in specific proportions. Other essential amino acids contained in SomaLife gHP are Isoleucine, Leucine, Lysine and Valine. Lysine boosts the effectiveness of Arginine and is also said to affect growth as well as having immune-boosting properties of its own. Ornithine can be synthesized in the body and is now also known to help stimulate HGH release. Glutamine can also be synthesized in the body but may not always be made by the body in sufficient quantities in times of stress. Dr. Klatz notes that the gastrointestinal tract and the immune system "practically live on it", and that without sufficiently available levels, the gastrointestinal tract does not function as well, and nutrients are less well absorbed.

The other amino acids in SomaLife gHP contribute to the effects of the supplement and the amino acids listed above. This type of combination of amino acids is known as an
amino acid stack. The SomaLife gHP patent pending formula offers the individual benefits of all of its amino acids and more. This formula is our effective means of increasing the body's natural production of HGH.

It is interesting to note that the body continues to make adequate amounts of HGH even into old age, at the same time the production of certain other hormones declines with age. Restoring HGH levels to those of youth levels meant finding products or supplements which would encourage the pituitary gland to release the HGH that it was already making. SomaLife gHP has been shown to be able to do this: restoring those youthful levels for most of us without overstimulating our production or subjecting us to injections of the hormone itself.

SomaLife gHP works as the ultimate dietary supplement by assisting the body's ability to secrete HGH naturally in a manner which is safe and effective as well as being affordable. Many individuals, when taking this dietary supplement, will notice an immediate effect with some of those improvements noted earlier. The scientific literature suggests that maximum effects occur over a three-to-six-month time frame. It is suggested that when starting SomaLife gHP, it should be taken for a minimum of three months, preferably along with a dietary and exercise regime in order to ensure maximal benefits.

SomaLife gHP has been formulated in capsule form for maximum ease of use as well as availability and absorption. Taken on an empty stomach, this is easily achieved by taking it half an hour before or two hours after eating. This ensures that it is rapidly absorbed into the bloodstream to derive maximum benefit. It is recommended that men take this product in a single serving of six capsules at bedtime and women in two servings of three capsules twice daily, on an empty stomach, to most accurately reflect the natural release of HGH in both men and women. Men release most of their HGH in a large spike about 90 minutes after falling asleep while in a deep sleep. Where as women tend to release HGH in smaller spikes over a 24-hour period.

In the August 16th, 2000 Journal of the "American Medical Association," Dr. Eve Van Cauter, one of the leading medical researchers in the world on HGH from the University of Chicago, published a paper in which she discussed the relationship between the declining HGH levels in men to their poorer sleeping patterns. As men age they secrete most of their growth hormone at night, as opposed to women who secrete it throughout the day. This might explain the longer life spans of women as shown by statistics.

Older individuals may need to start with just one capsule per day and gradually increase dosage to a full serving by adding an extra capsule every 5 to 7 days. SomaLife gHP is formulated from natural ingredients and contains no animal-derived products in its proprietary formulation, ensuring maximum benefits for all, without risk or side effects.

Much of this information will be new to individuals who are interested in anti-aging, a field which is just on the
verge of exploding into the public domain. Almost daily, articles appear in newspapers and magazines with regard to ways in which we may be able to slow down or even reverse the aging process. On December 14, 1998, a paper delivered at the American Society of Cell Biology Convention in San Francisco by Professor Lee Sweeney, the leader of a team of geneticists at the University of Pennsylvania in Philadelphia, showed that age-related muscle loss in mice could be reversed by inserting a fresh copy of a gene for IGF-1 into cells. One day this may be used to treat muscle-wasting diseases as well as preventing the weakness and shrinkage of muscles in old age. This discovery was described by David Derbyshire in the British newspaper, "The Daily Mail" on Tuesday, December 15, 1998, as having the potential for "a magic bullet of youth."

Raising HGH levels increases IGF-1 levels. This can be achieved by SomaLife gHP without the need for expensive injection therapy, oral-HGH forms, or as shown most recently at the University of Pennsylvania, gene manipulation which will undoubtedly be expensive.

SomaLife Health Products Inc. is a North American based nutraceutical company. Its state-of-the-art research and development laboratory, coupled with a scientific team of MD's, PhD's, Pathologists, Biochemists and Senior Physicians in longevity & anti-aging clinics across North America, places SomaLife Health Products Inc. at the forefront of this technology. Senior members of the CLA4 (Canadian Longevity and Anti-aging Academy) make up SomaLife's medical advisory board, and are dedicated to the research and development of SomaLife products. SomaLife's mission is to improve and maintain one's health through the use of these all-natural products, thus allowing all of us to truly enjoy those golden moments.


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